| 摘要 |
NEW MATERIAL:A compound expressed by formula I {R<1> represents (protected) carboxyl or carboxylate; R<2> represents (protected) hydroxy lower alkyl; R<3> represents H or lower alkyl; A represents formulae II or III [formula IV represents N-containing aliphatic heteroring optionally further containing other heteroatom; R<4> represents H, (protected) OH, (protected) hydroxy lower alkyl, etc.; R<5> represents H, lower alkenyl, carbonyl, etc.; m and n are 0-3]}. EXAMPLE:Allyl (5R,6S)-3-(1-allyloxycarbonyl-1,2,3,6-tetrahydropyridin-4-yl)-6-[(1 R)-1-tertiary butyldimethylsilyloxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2- carboxylate. USE:An antimicrobial agent. PREPARATION:Compounds (salts) expressed by formula V are cyclized. |
