发明名称 |
PROCESS FOR DEBLOCKING ALLYL ESTERS BY MEANS OF REPRODUCIBLE POLYMER- CARRIED PD(O) |
摘要 |
<p>PURPOSE: To deprotect a protecting group and to regenerate a catalyst by allowing a compd. having a protecting group such as an allyl ester to react with polymer-supported Pd(O) in the presence of a nucleophilic agent. CONSTITUTION: About 1 equiv. compd. having a protecting group such as allyl ester or allyl carbonate is allowed to react with a catalytic amt. of polymer- supported Pd(O) in the presence of >=1 equiv. nucleophilic agent such as 1,3- cyclopentanedione and one-step operation is carried out. The polymer-supported Pd(O) is a complex of a polystyrene-bonded triphenylphosphine and a tetrakistriphenylphosphine in a molar ratio of about (30-50):1. The protecting group is deprotected with the polymer-supported Pd(O) and then the polymer- supported Pd(O) is regenerated.</p> |
申请公布号 |
JPH02290256(A) |
申请公布日期 |
1990.11.30 |
申请号 |
JP19900044286 |
申请日期 |
1990.02.23 |
申请人 |
MERCK & CO INC |
发明人 |
DEIBUITSUDO EMU CHIEEN;EFU EDOWAADO ROBAATSU;TOMASU AARU BUAAHOOBUEN |
分类号 |
C07D477/00;B01J31/06;B01J31/16;B01J31/24;B01J31/28;B01J31/40;C07D477/08;C07D501/04 |
主分类号 |
C07D477/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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