发明名称 PROCESS FOR PRODUCING INTERMEDIARY COMPOUNDS FOR THE PURPOSE OR OBTAINING TETRAZOLE DERIVATIVES REDUCING PATHOLOGICALLY HIGH CHOLESTERIN LEVEL OF BLOOD
摘要 This invention provides novel tetrazole intermediates of the formula <IMAGE> wherein R1 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy or trifluoromethyl; R2,R3,R5 and R6 each are independently hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy; B is hydrogen, C1-4 alkoxycarbonyl, CH2Y or CH2Z; Y is hydrogen, hydroxyl or X; Z is <IMAGE> X is bromo, chloro or iodo; R10 is C1-4 alkyl; and R11 is phenyl which is unsubstituted or substituted by one or two C1-4 alkyl or chloro substituents. and processes thereof which are useful for the preparation of antihypercholesterolemic agents.
申请公布号 HU201533(B) 申请公布日期 1990.11.28
申请号 HU19880005124 申请日期 1988.02.24
申请人 BRISTOL-MYERS CO.,US 发明人 WRIGHT,JOHN JESSEN,US;SIT,SING-YUEEN,US;BALASUBRAMANIAN,NEELAKANTAN,US;BROWN,PETER J.,US
分类号 A61K31/41;A61P3/06;C02F11/00;C07D257/04;C07D405/06;C07F9/6524 主分类号 A61K31/41
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