| 摘要 |
Novel thiazolones of the formula: or a tautomer thereof, wherein Y is an oxygen or sulfur group; R1 is a hydrogen or a (C1-C5) alkyl group where R2 is R; R2 is a hydrogen or a (C1-C5) alkyl group where R1 is R; and R is a phenyl group optionally substituted wlth one or two members of the group consisting of (C1-C5) alkyl, (C1-C5) alkoxy, (C1-C5) alkylthio, (C1-C5) alkylsulfinyl, (C1-C5) alkulsulfonyl, hydroxy, halogen, cyano, carboxy, carb(C1-C5)alkoxy, (C1-C5) alkanoylamino, imidazolyl or trifluoromethyl, or with a methylenedioxy group, or a 2-, 3- or 4-pyridyl group optionally substituted with a hydroxy, halogen, (C1-C5) alkyl, (C1-C5) alkoxy, (C1-C5) alkylthio, (C1-C5) alkylsulfinyl, (C1-C5) alkylsulfonyl, cyano, carboxy, carb(C1-C5)alkoxy, (C1C5)alkanoylamino or imidazolyl, or a 2- or 3furanyl, 2- or 3-thienyl or 2- or 3-pyranyl group; enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure. |
