发明名称 |
Cyano:formate ester prodn. from corresp. chloro:formate - by reaction with hydrogen cyanide in presence of base, intermediates for pharmaceuticals and plant protection agents |
摘要 |
Prodn. of cyanoformate esters of formula (I) comprises reacting chloroformate (II) with HCN, in presence of base and under anhydrous conditions, where. R = opt. substd. lower alkyl, lower alkenyl, phenyl or benzyl. The base is Et3N and reaction is in one or more apolar, aprotic solvents, esp. aromatic hydrocarbons. USE/ADVANTAGE - (I) are intermediates for pharmaceutically and plant-protection agents. This method provides better than 80% yield and 98% purities. Unlike known processes, it does not require expensive starting materials or catalysts, so is suitable for industrial operation.
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申请公布号 |
CH675875(A5) |
申请公布日期 |
1990.11.15 |
申请号 |
CH19880003802 |
申请日期 |
1988.10.13 |
申请人 |
LONZA AG, GAMPEL/WALLIS. GESCHAEFTSLEITUNG |
发明人 |
METTLER, HANSPETER, DR.;PREVIDOLI, FELIX, DR. |
分类号 |
C07C255/18 |
主分类号 |
C07C255/18 |
代理机构 |
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