发明名称 |
Enzymatic removal of a protein amino-terminal sequence. |
摘要 |
<p>This disclosure relates to new compounds and to a process for the controlled conversion of such compounds to produce a Protein that comprises an amino acid sequence which is useful as a precursor to human insulin or to a modified human insulin, the amino terminus portion of which sequence does not define a cathepsin C dipeptide removal stop point. The compounds have the formula Met-Y-Protein in which Y is Tyr or Arg.</p> |
申请公布号 |
EP0397420(A1) |
申请公布日期 |
1990.11.14 |
申请号 |
EP19900304890 |
申请日期 |
1990.05.04 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
BECKER, GERALD WAYNE;FURMAN, THOMAS CHARLES;MACKELLAR, WARREN C.;MCDONOUGH, JAMES PATRICK |
分类号 |
C12P21/02;A61K38/28;C07K1/02;C07K1/107;C07K1/12;C07K14/00;C07K14/575;C07K14/62;C12N15/09;C12N15/17;C12P21/06 |
主分类号 |
C12P21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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