| 摘要 |
Prepn. of 3-hydroxy-3-methylglutaric acid (HOOCCH2)2C(OH)CH3) (I) comprises oxidn. of 4-methyl-1,6-heptadien-4-ol (CH2=CHCH2)2C(OH)CH3) (II) in presence of a phase-transfer catalyst. Reaction is pref. at 30-70 degrees esp. 50-60 degrees C in aq. benzene using KMnO4 as oxidising a agent and a cetyl-trimethylammonium halide as catalyst. (I) is a known hypolipidaemic agent. High yields are obtd. without use of dangerous reagents such as O3. |
