N-(5,6,7,8-TETRAHYDROPYRIDO(2,3-D)PYRIMIDIN-6-YL-ALKANOYL)-GLUTAMIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS

摘要

A compound selected from the group consisting of a glutamic acid derivative of the formula: in which: R<1> is -OH or -NH2; R<2> is hydrogen or a carboxy protecting group; R<3> is a carbon-carbon bond, alkylene of 1 to 4 carbon atoms, cyclohexylene, or R<4> is hydrogen or an amino protecting group; Q is -S- or -O-; R<5> is hydrogen, chloro or fluoro; and the configuration about the carbon atom designated * is S; and the pharmaceutically acceptable salts thereof. Also disclosed is a method of combatting neoplastic growth in a mammal and a pharmaceutical composition for combatting neoplastic growth in a mammal making use of the above compound.