| 摘要 |
<p>This invention relates to compounds of structural formula (I) <CHEM> and tautomeric forms thereof wherein R<1> and R<2> are independently hydrogen, lower alkyl containing 1 to 6 carbon atoms, alkoxy containing 1 to 6 carbon atoms, ethynyl, methylthio, nitro, halogen,nitrile, trifluoro-methyl, vinyl or benzyloxy in which the phenyl group is optionally substituted by one or more substituents selected from halogen,lower alkyl containing 1 to 6 carbon atoms and alkoxy containing 1 to 6 carbon atoms; Z is <CHEM> wherein R<3> is hydrogen, lower alkyl containing 1 to 3 carbon atoms, alkoxy containing 1 to 2 carbon atoms, or benzyl; R<4> is lower alkyl containing 1 to 3 carbon atoms, alkoxy containing 1 to 2 carbon atoms, or benzyl; n<1> is 0, 1 or 2; n<2> is 0, 1 or 2; or Z is -S-CH2-, -SO2-CH2, or -OCH2-; or Z is -C(R<5>)=C(R<6>)-, wherein R<5> and R<6> are independently hydrogen or lower alkyl containing 1 to 3 carbon atoms and their pharmaceutically acceptable salts. The compounds have pharmaceutical properties which render them beneficial for the treatment of diabetes mellitus and associated conditions. The invention also provides processes for their preparation, methods of using the compounds and pharmaceutical compositions containing them.</p> |
