发明名称 |
NEW 3'-(4-MORPHOLINYL)- AND 3'-(2-METHOXY-4-MORPHOLINYL)- ANTHRACYCLINE DERIVATIVES |
摘要 |
Anthracycline glycosides of general formula I: <CHEM> wherein Z is hydrogen or methoxy; X represents hydrogen or hydroxy; R1 represents hydrogen, fluorine, hydroxy, methoxy or amino; R2 and R3 both represent hydroxy or one of R2 and R3 is hydrogen, nitro or amino and the other is hydroxy; and R4 and R5 represent hydrogen or one of R4 and R5 is hydrogen and the other is hydroxy; and pharmaceutically acceptable salts thereof; with the provisos that: (i) when R2 and R3 are both hydroxy and Z is hydrogen then R1 represents hydroxy, fluorine or amino, and (ii) when both Z and R1 are methoxy and R2 and R3 are both hydroxy then R5 is hydroxy or both R4 and R5 are hydrogen. |
申请公布号 |
WO9010639(A3) |
申请公布日期 |
1990.10.18 |
申请号 |
WO1990EP00387 |
申请日期 |
1990.03.09 |
申请人 |
FARMITALIA CARLO ERBA S.R.L. |
发明人 |
SUARATO, ANTONIO;ANGELUCCI, FRANCESCO;BARGIOTTI, ALBERTO;GRANDI, MARIA;PEZZONI, GABRIELLA |
分类号 |
A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61K31/7042;A61K31/7052;A61P35/00;C07H15/252;C07H19/02 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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