CONSTRUCTION AND USE OF SYNTHETIC CONSTRUCTS ENCODING SYNDECAN

摘要

A purified mammalian peptide, and genetic information encoding such peptides, having a molecular weight of from about 31 kD to about 35 kD and comprising an amino terminus extracellular region, a carboxy terminus cytoplasmic region, and a transmembrane region between said cytoplasmic and extracellular regions, a dibasic sequence extracellularly adjacent the transmembrane region of the peptide, and at least one glycosylation site in the extracellular region including an Xac-Xaa-Ser-Gly-Xac sequence, wherein Xac is an acidic amino acid and Xaa is any amino acid. Additional peptides having this glycosylation site and genetic information useful for preparing a number of variations based on this peptide are also provided.