| 摘要 |
<p>The invention is N-acyl and dihydro-N-acyl analogs of formula (I) of the family of antibacterial and antitumor agents known collectively as the E33288 complex. <CHEM> wherein W is <CHEM> R is hydrogen or a branched or unbranched alkyl (C1-C10) or alkylene (C1-C10) group, an aryl or hetero-aryl group, or an aryl-alkyl (C1-C5) or hetero-aryl-alkyl (C1-C5) group, all optionally substituted by one or more hydroxy, amino, carboxy, halo, nitro, lower (C1-C3) alkoxy, or lower (C1-C5) thioalkoxy groups; R1 is H or <CHEM> R2 is CH3, C2H5 or CH(CH3)2; R4 is OH when R5 is H or R4 and R5 taken together are a carbonyl; and X is an iodine or bromine atom.</p> |
