ENZYMATIC PRODUCTION OF 7-AMINO CEPHALOSPORANIC ACID

摘要

2049958 9012110 PCTABS00002 An enzymatic process for the production of 7-amino cephalosporanic acid from cephalosporine C is disclosed. The process is a two-stage enzymatic reaction which can be performed in a single reactor. The invention further includes a mutant strain of Trigonopsis variabilis which produces increased amounts of D-amino acid oxidase, and a mutant strain of Acinetobacter spp., which increased amounts of deacylase, which are enzymes necessary for the present process.