| 摘要 |
<p>The invention provides thiazole compounds and pharmacologically acceptable salts thereof excellent in analgesic, antiinflammatory and antipyretic activities, represented by general formula (I), wherein R?1 and R2¿ represent each independently hydrogen, halogen, alkyl, alkenyl, nitro, CF¿3?, phenyl, substituted phenyl, pyridyl, substituted pyridyl, carboxyl, alkoxycarbonyl, -CONR?5R6¿ (wherein R?5 and R6¿ represent each hydrogen or alkyl), acyl, hydroxy, alkoxy or thioalkyl, or alternatively R?1 and R2¿ are combined together to form -(CH¿2?)m- (wherein m is 3 to 5); R?3¿ represents hydrogen or alkyl; R4 represents hydroxy, alkoxy or -NR7R8 (wherein R?7 and R8¿ represent each hydrogen or alkyl); X represents carbonyl or -(CH¿2?)n- (wherein n is 0 or 1); and Y represents hydrogen, halogen, alkyl, nitro, CF3, -NR?9R10¿ (wherein R?9 and R10¿ represent each hydrogen or alkyl), hydroxy (only when the position of X is para to the CHR3COR4 group), alkoxy (only when the position of X is para to the CHR3COR4 group), or alkylthio.</p> |
