发明名称 |
FORMULATIONS FOR STABILIZING OF IgM ANTIBODIES |
摘要 |
Compositions suitable for intraveneous injection are disclosed, which comprise a stabilizing buffer solution containing IgM antibodies. The compositions are effective in stabilizing the antibodies in solution, inhibiting precipitation and the formation of particulates in the final product vial, while maintaining a high level of immunoreactivity. The compositions can be lyophilized to form dry, stable products which can be readily reconstituted to provide injectable, particle-free antibody solutions. |
申请公布号 |
WO9011091(A1) |
申请公布日期 |
1990.10.04 |
申请号 |
WO1990US01383 |
申请日期 |
1990.03.13 |
申请人 |
CENTOCOR, INC. |
发明人 |
BOLMER, SALLY;MATTIS, JEFFREY, A.;PHILLIPS, CHRISTOPHER, P. |
分类号 |
A61K9/08;A61K9/14;A61K39/395;A61K47/02;A61K47/04;A61K47/12;A61K47/18;A61K47/22;A61K47/42 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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