| 摘要 |
The present invention relates, by way of novel industrial products, to the following oxyimino derivatives of thiazole: (a) the E and Z diastereoisomers of the formula <IMAGE> (1) in which R1 represents H, F, Cl, Br, CF3 or CH3 and R2 represents a C1-C10-alkyl group, a benzyl group of the formula CH2C6H2(R3)3, in which each R3 identical or different represents H, F,Cl,Br, CF3, a C1-C4-alkyl group or a C1-C4-alkoxy group, a group CH2COOR4, in which R4 represents H, a C1-C4-alkyl group or the ammonium group, NH4+, a group CH2COOMm, in which M is an alkali metal or alkaline earth metal and m is its valency, or a 2-aminoethyl group of the formula CH2CH2NR5R6, in which R5 and R6, which can be identical or different each represent H or a C1-C4-alkyl group, it being possible for R5 and R6, taken together with the nitrogen atom to which they are bonded, to form a 5-to 7-membered N-heterocyclic group which may contain a second heteroatom selected from N, O and S and may be substituted, it also being possible for R2 to represent the hydrogen atom when R1 is other than H, and mixtures of the said E and Z isomers; and (b) the addition salts of the said E and Z isomers and of mixtures thereof. These novel derivatives, as well as the compound of formula I in which R1=R2=H, are useful in therapy as anticonvulsants.
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