发明名称 |
PROCESS FOR THE PREPARATION OF ACRYLOYL-PIPERAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
摘要 |
Compounds of formula (I): <CHEM> [in which R<1> and R<2> is each -R<5>, -CH=CH-R<5> or -C IDENTICAL C-R<5>, in which R<5> is optionally substituted aryl or aromatic heterocyclic; R<3> is hydrogen, alkyl, cyano or -R<5>; X is oxygen or sulphur; A is 1,4-piperazin-1,4-diyl or a 1,4-homopiperazin-1,4-diyl; B is alkylene, carbonyl, thiocarbonyl, sulphinyl or sulphonyl; and R<4> is optionally substituted phenyl] and pharmaceutically acceptable salts thereof have valuable PAF antagonist activity, and may be prepared by reacting a compound containing the piperazine or homopiperazine part of the molecule with a compound containing the other part of the molecule. |
申请公布号 |
HU902624(D0) |
申请公布日期 |
1990.09.28 |
申请号 |
HU19900002624 |
申请日期 |
1990.04.28 |
申请人 |
SANKYO CO. LTD.,JP |
发明人 |
NAKAMURA,NORIO,JP;OHKAWA,NOBUYUKI,JP;OSHIMA,TAKESHI,JP;MILYAMOTO,MASAAKI,JP;TIJIMA,YASUTERU,JP |
分类号 |
C07D295/04;A61K31/38;A61K31/44;A61K31/495;A61P1/04;A61P7/02;A61P9/00;A61P9/12;A61P13/02;A61P15/00;A61P43/00;C07D213/56;C07D215/14;C07D243/08;C07D295/18;C07D295/185;C07D295/192;C07D295/194;C07D295/26;C07D317/60;C07D333/24;C07D401/06;C07D409/06 |
主分类号 |
C07D295/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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