| 摘要 |
Substituted 1,2,4-triazolo[1,5-c]pyrimido[1,4]-azines of formula <CHEM> wherein A is methylene or carbonyl; B is methylene, carbonyl or -CHR9-; Q is N-R7 or O; Y is N-R10, O, S, SO or SO2; R2 is hydrogen or alkyl; R5 is alkyl; R7 is hydrogen, alkyl, benzyl or acetyl; R9 is alkyl; R10 is alkyl or benzyl; have been found to have potent bronchodilator activity. Pharmacological methods for inducing bronchodilation using such compounds, pharmaceutical compositions containing such compounds, and synthetic intermediates for preparing such compounds are also described. |
