发明名称 |
A UV-INDUCED FACTOR FOR IMMUNOSUPPRESSION |
摘要 |
The present invention comprises the method of selectively suppressing an immune response of a mammal to a particular alloantigen. The method includes several steps. One step is administering to a mammal an effective amount of UVB-radiation. Epidermal cell cultures, when subjected to UVA or UVB irradiation produce specific immunosuppressive factors. This UV-radiation is preferably UVA radiation (320 nm to 400 nm), or UVB-radiation (280 nm to 320 nm). It is demonstrated herein that UVA radiation results in in vitro cells producing a factor which selectively suppresses the CHS response in mammals, while UVB radiation selectively suppresses the DTH response in mammals. Another step of the inventive method involves desensitizing a mammal to a particular alloantigen. It has been determined that a mammal will become tolerant to a particular alloantigen once the subject mammal has been irradiated with a predetermined wavelength of UVR and thereafter sensitized with the particular alloantigen. This may analogously be accomplished using factors from in vitro epidermal cell cultures. |
申请公布号 |
WO9010461(A1) |
申请公布日期 |
1990.09.20 |
申请号 |
WO1990US01402 |
申请日期 |
1990.03.14 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
ULLRICH, STEPHEN, E. |
分类号 |
A61K38/00;A61K39/00;A61K41/00;A61N5/06;A61P37/06;C07K1/22;C07K14/435;C07K14/54 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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