| 摘要 |
The invention relates to novel DELTA <1><4>-16 alpha ,17-dihydroxy-pregnane-16,17-cyclic aldehyde acetal and -cyclic ketone ketal derivatives of general formula (I), <CHEM> wherein A stands for hydrogen or hydroxyl group; X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen; R stands for hydrogen,benzoyl or C1<->8alkanoyl group; R<1> and R<2>, which are the same or different, stand for hydrogen or a C1<->4alkyl group; or one of R<1> and R<2> is hydrogen and the other is phenyl group; or R<1> and R<2> together form a C4<->5alkylene group; --- means a single or double bond between two adjacent carbon atoms, as well as pharmaceutical compositions containing these compounds and a process for their preparation. The compounds of general formula (I) possess a very strong antiinflammatory effect and only week harmful side effect. Thus, they can be used as active ingredients of antiinflammatory pharmaceutical compositions being useful in the therapy. |
