HORMONE RESPONSE ELEMENT COMPOSITIONS AND ASSAY

摘要

The present invention discloses steroid/thyroid hormone receptor DNA binding domain compositions that determine tar- get gene specificity. The invention further discloses methods converting the target gene specificity of one receptor into the target gene specificity of another. Still further the invention discloses novel assays for identifying ligands for orphan. hormone receptors. These assays are especially useful since they avoid the necessity of constructing chimeric genes and proteins in order to search for ligands that can activate a putative receptor.