发明名称 |
WS7622A, B, C AND D SUBSTANCES, DERIVATIVES THEREOF, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF |
摘要 |
These substances which are produced by culturing a strain of the genus Streptomyces in a nutrient medium have a human leukocyte elastase-inhibiting activity. Derivatives of the WS7622A substance having formula I are also disclosed: wherein R1 and R2 are each lower alkyl groups or lower alkanoyl groups. These substances, derivatives and pharmaceutically acceptable salts can be used as human leukocyte elastase inhibitors for treating degenerative diseases, for example, pulmonary emphysema, atherosclerosis, rheumatoid arthritis, osteoarthritis, psoriasis, pancreatitis, adult respiratory distress syndrome and the like. Pharmaceutical compositions containing these substances, derivatives and salts are also described as well as a method of treating the above diseases.
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申请公布号 |
CA2012074(A1) |
申请公布日期 |
1990.09.14 |
申请号 |
CA19902012074 |
申请日期 |
1990.03.13 |
申请人 |
FUJISAWA PHARMACEUTICAL CO., LTD. |
发明人 |
HATANAKA, HIROSHI;EZAKI, MASAMI;TSUJII, EISAKU;OKAMOTO, MASANORI;SHIGEMATSU, NOBUHARU;OKUHARA, MASAKUNI;TAKASE, SHIGEHIRO |
分类号 |
C12P1/04;A61K35/74;A61P1/00;A61P9/10;A61P11/00;A61P17/00;A61P29/00;A61P43/00;C07G99/00;C12P1/06;C12R1/465;(IPC1-7):C12P1/06;C12N1/00 |
主分类号 |
C12P1/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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