摘要 |
Disclosed are compounds of formula (1.0) wherein R<13> represents an imidazole ring; R<14> represents a carbamate, urea, amide or sulfonamide group; R<8> represents H when the alkyl chain between the amide group and the R<13> imidazole group is substituted, or R<8> represents a substituent such aa arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R<8> is H, and the alkyl chain between the amide group and the R<13> imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
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申请人 |
SCHERING CORPORATION |
发明人 |
TAVERAS, ARTHUR, G.;DOLL, RONALD, J.;COOPER, ALAN, B.;FERREIRA, JOHAN, A.;GUZI, TIMOTHY;MALLAMS, ALAN, K.;RANE, DINANATH, F.;GIRIJAVALLABHAN, VIYYOOR, M.;AFONSO, ADRIANO;AKI, CYNTHIA, J.;CHAO, JIANPING;ALVAREZ, CARMEN;KELLY, JOSEPH, M.;LALWANI, TARIK;DESAI, JAGDISH, A.;WANG, JAMES, J., S.;WEINSTEIN, JAY |