| 摘要 |
NEW MATERIAL:The compound of formula I [R1 is H, (protected) hydroxy-lower alkyl, etc.; COOR2 is (protected) carboxyl, etc.; R3 is lower alkyl; R4 is group of formula II (the group of formula III constituting the partial structure of R4 is 5-membered or 6-membered nitrogen-containing heterocyclic group containing 1-4 hetero atoms selected from O, S and N; R5 is H, nitro, etc.)]. EXAMPLE:(1R,5S,6S,8R)-2-[(6,7-dihydro-5H-pyrrolo-[1, 2-C]imidazol-7-yl)thio]-6-(1- hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylic acid. USE:Antibacterial agent against bacteria resistant to cephalosporin or penicillin, Gram-positive bacteria and Gram-negative bacteria. PREPARATION:The objective compound of formula I is produced by oxidizing a compound of formula IV (R2 is ester residue; R7 is methyl, etc.) with peracetic acid, etc., in a solvent, substituting the resultant compound of formula V with a thiol compound of formula VI in methanol, etc., and, as necessary, deprotecting the product. |
