Conjunction of polymer to colony stimulating factor-1 - retaining biological activity while increasing circulating in vivo half-life in mammals

摘要

A biologically active compsn. is claimed comprising a protein that stimulates the formation of primarily macrophage colonies in the in vitro colony stimulating factor-1 (CSF-1) assay, which protein is covalently conjugated to a water-soluble polymer selected from polyethylene or polypropylene glycol homopolymers, polyoxyethylated polyols and polyvinyl alcohol, where the homopolymer is unsubstd. or substd. at one end with an alkyl gp.