发明名称 1,2,3,4-TETRAHYDRO-1,9-ACRIDINEDIAMINES,A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
摘要 There are disclosed compounds having the formula <CHEM> where n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro or trifluoromethyl; R1 and R2 are each independently hydrogen, loweralkyl or arylloweralkyl, but both may not be arylloweralkyl simultaneously; R3 and R4 are each independently hydrogen, loweralkyl, arylloweralkyl, formyl or loweralkylcarbonyl, or alternatively the group -NR3R4 taken as a whole constitutes <CHEM> stereo isomers thereof and pharmaceutically acceptable acid addition salts thereof and a process for their preparation. The compounds are useful for the treatment of various memory dysfunctions characterized by decreased cholingeric function, such as Alzheimer's disease, and can, therefore, be used as medicaments.
申请公布号 ZA8908498(B) 申请公布日期 1990.08.29
申请号 ZA19890008498 申请日期 1989.11.08
申请人 HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED 发明人 GREGORY M. SHUTSKE;KEVIN J. KAPPLES
分类号 A61K31/435;A61P25/28;C07D219/10;C07D221/16;C07D401/04 主分类号 A61K31/435
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