Alkali metal salts of 3,7-substituted 7-aminocephalosporanic acid derivatives and the process for preparing the same.

摘要

An alkali metal salt of 3, 7 - substituted 7 - aminocephalosporanic acid derivatives having the general formula: <CHEM> wherein: <CHEM> or <CHEM> R1 = CH3 or C1 M = Na or K and the process for producing the salt from the acid-form derivatives. The process includes preparing a 30% suspension by weight of the acid-form derivative in concentrate alcohol containing 3 to 7% of water by weight and add an alcoholic solution of alkali base to the suspension under room temperature. The alcohol used to dissolve the base also containes 3 to 7% of water. After a reaction time of 5 to 20 minutes, cool the mixture and let the salt crystallize, and separate the latter from the liquid phase.