发明名称 |
PROCESS FOR PRODUCING ENANTIOMER OF AMLODIPINE IN HIGH OPTICAL PURITY |
摘要 |
<p>The present invention relates to a process for preparation of optically pure (S)-amlodipine-L-hemitartrate DMF solvate comprising the steps of treating (R,S) amlodipine base with L-tartaric acid in the presence of dimethyl formamide and a co-solvent. The invention also relates to a process for converting (R) or (S)-amlopidine-L-hemitartrate DMF solvate into their besylates without isolating free chiral amlopidine base after solution.</p> |
申请公布号 |
PT1802576(E) |
申请公布日期 |
2008.09.15 |
申请号 |
PT20050792229T |
申请日期 |
2005.10.17 |
申请人 |
EMCURE PHARMACEUTICALS LIMITED |
发明人 |
MILIND MORESHWAR GHARPURE;BABURAO MANIKRAO BHAWAL;PRASAD VASUDEO RANADE;RAJENDRA DAGADU DESHMUKH;SATISH RAMANLAL MEHTA |
分类号 |
C07D211/90 |
主分类号 |
C07D211/90 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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