摘要 |
The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML). A compound comprising Formula (1 ) wherein: Z is independently selected from the group consisting of CH2, O, C(O), and CH, wherein when Z is CH, Z is connected to Y via a double bond and Y is N. |
申请人 |
BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS;THE REGENTS OF THE UNIVERSITY OF COLORADO |
发明人 |
JANGANATI, VENUMADHAV;CROOKS, PETER;PENTHALA, NARSIMHA REDDY;JORDAN, CRAIG;BOMMAGANI, SHOBANBABU;PONDER, JESSICA |