5-SUBSTITUTED URIDINE DERIVATIVES AND INTERMEDIATES FOR THEIR PREPARATION.

摘要

5-substituted uridine derivatives of formula (I) and their salts; and 5-substituted-5'-trityl uridine derivatives of formula (II) are new: where X is F or trifluoromethyl; R1 and R2 are -OSiR4R5R6, OH, aminoacyloxy (the amino group of which may be substd. by lower alkyl) or carboxyalkylcarbonyloxy; R4-R6 are 1-10C alkyl, -(CH2)nPh or -SiR7R8(OH); n is 0-2; R7 and R8 are lower alkyl; R3 is -OSiR4R5R6, H, OH, aminoacyloxy (the amino group of which may be substd. by lower alkyl) or carboxyalkylcarbonyloxy; at least one of R1-R3 is -OSiR4R5R6; when X is F, then R3 is not H; R21 is OH or -OSiR4R5R6; R31 is H, OH or -OSiR4R5R6.