| 摘要 |
PURPOSE: To prepare a pharmaceutical composition for treating tumor, comprising a tumor necrosis factor(TNF) and dipyridamole or its salt and having enhanced antitumor actions of the TNF. CONSTITUTION: This pharmaceutical composition comprises a TNF composed of TNF-α, TNF-βor a combination thereof and dipyridamole: 2,6-bis(diethanolamino)-4,8-piperidino-pyrimido[5,4-d]pyrimidine or its salt. The ingredients are substantially administered together to a patient suffering from tumor. The preferred amounts thereof in blood plasma for treating the tumor are within the following ranges: 1-5,000U/mL TNF and 0.1-200μM dipyridamole. The TNF is administered as an intamuscular or a subcutaneous injection in preferably about 5×10<6> to 5×10<8> U, more preferably 7×10<6> to 3.5×10<7> U daily dose once and dipyridamole is orally and daily administered in 25-125mg, preferably 30-60mg dose twice.
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