发明名称 |
SELECTION METHOD FOR SPECIFIC USEFUL PHARMACEUTICAL COMPOUNDS |
摘要 |
The present invention provides a predictive method for selecting organic compounds having useful pharmaceutical activity in a mammal. The method uses volume areas of similar molecules. When specific substituents of the test compound file predetermined volumes, the compound is subject to a binding assay. Only when the binding assay is positive, is the experimental compound recommended for further pharmaceutical evaluation. Example compounds are derivatives of 4-substituted 2,6-diiodophenols of the structure (I), where R<1> and R<2> are defined as aliphatic or substituted aliphatic moieties or aromatic or substituted aromatic moieties. Useful structures are described. The compounds have useful pharmaceutical properties to treat conditions in a human being, including hyperthyroidism, angina pectoris, arrythmia, and the like. |
申请公布号 |
WO9007330(A1) |
申请公布日期 |
1990.07.12 |
申请号 |
WO1990US00109 |
申请日期 |
1990.01.05 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;STEARNS, JAY, F. |
发明人 |
STEARNS, JAY, F.;LAVIN, THOMAS, N. |
分类号 |
A61K31/085;C07C217/22;C07C229/36;C07D209/14;C07D307/80 |
主分类号 |
A61K31/085 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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