发明名称 |
Bispecific monoclonal antibody, its production and use. |
摘要 |
<p>A bispecific monoclonal antibody to an ansamitocin derivative and a target antigen, particularly tumor-associated antigen, can carry an ansamitocin derivative in a stable and inactive form at other sites than the target and release the active-form ansamitocin derivative at the target site, so that an anticancer agent having excellent durability and selectivity with little adverse action can be prepared using the bispecific monoclonal antibody and ansamitocin derivatives.</p> |
申请公布号 |
EP0376176(A2) |
申请公布日期 |
1990.07.04 |
申请号 |
EP19890123718 |
申请日期 |
1989.12.22 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
IWASA, SUSUMU;HARADA, KAORI;TOYODA, YUKIO |
分类号 |
A61K31/535;A61K38/00;A61K47/48;C07K16/14;C07K16/30;C07K16/44;C07K16/46;C12P21/08 |
主分类号 |
A61K31/535 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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