发明名称 4((6-OXO-5PYRIMIDINYL)ALKYLAMINO)BENZOYLGLUTAMIC ACID DERIVATIVES
摘要 The present invention provides a compound of formula (I): <CHEM> wherein R<1> is hydrogen, C1-4 alkyl, acetyl or formyl; R<2> and R<3> are the same or different and are hydrogen or C1-4 alkyl; R<4> is NR<1><1>R<1><2>; R<1><1>, R<1><2>, R<5> and R<6> are the same or different and are hydrogen, C1-4 alkyl or C1-12 acyl; R<7>, R<8>, R<9> and R<1><0> are the same or different and are hydrogen, halo, C1-4 haloalkyl, C1-4 alkyl and C1-4 alkoxy; and n is 2, 3, 4 or 5; m is o or an integer from 1 to 6; or a salt thereof, methods for the preparation of the compounds of the formula (I), intermediates in their preparations, pharmaceutical formulations containing them, and their use in the treatment of tumours.
申请公布号 AU598307(B2) 申请公布日期 1990.06.21
申请号 AU19870079871 申请日期 1987.10.16
申请人 THE WELLCOME FOUNDATION LIMITED 发明人 JAMES LEROY KELLEY
分类号 A61K31/505;A61K38/00;A61P35/00;C07D239/48;C07D239/49;C07D249/08;C07D471/04;C07K5/02;C07K7/02 主分类号 A61K31/505
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