| 摘要 |
NEW MATERIAL:An aminoglycoside compound expressed by formula I (R1 and R4 are methyls or H; R2 is OH or H; R3 is amino or OH; R2 is OH when R4 is methyl, and H when R4 is H), or its acid addition salt. EXAMPLE:4''-C-methyl-3''-N-methylkanamycin A expressed by formula II. USE:An antimicrobial agent having a wide range of activites against Gram-positive and Gram-negative bacteria. PROCESS:A strain capable of producing gentamicin (or its variant), preferably Micromonospora sp.K-6993 or K-6993-Y-41 (FERM-P No.4304 or 4305), belonging to the genus Micromonospora is incubated in a culture medium containing kanamycin A or B at 28-32 deg.C under neutral pH conditions for 3-7 days. The resulting antibiotic is then separated and purified. |
