发明名称 |
(1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives. |
摘要 |
Novel (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives of formula <CHEM> the pharmaceutical acceptable acid addition salts thereof and the stereochemically isomeric forms thereof, wherein -X<1>=X<2>- is -CH=CH-, -CH=N-, or -N=CH-; R is hydrogen or C1-6alkyl; Y is hydrogen, C1-10alkyl, C3-7cycloalkyl, Ar<1>, Ar<2>-C1-6alkyl, C2-6alkenyl or C2-6alkynyl; Z is a radical of formula <CHEM> <CHEM> which compounds are useful for treating disorders which are characterized by an excessive proliferation and/or abnormal differentiation of epithelial tissues: pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.
|
申请公布号 |
EP0371564(A2) |
申请公布日期 |
1990.06.06 |
申请号 |
EP19890203014 |
申请日期 |
1989.11.28 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
FREYNE, EDDY JEAN EDGARD;VENET, MARC GASTON;RAEYMAEKERS, ALFONS HERMAN MARGARETHA;SANZ, GERARD CHARLES |
分类号 |
C07D401/06;A61K31/00;A61K31/47;A61K31/4704;A61K31/4709;A61K31/495;A61K31/498;A61K31/505;A61K31/517;A61K31/529;A61P5/26;A61P35/00;A61P43/00;C07D401/14;C07D403/06;C07D403/14;C07D407/14;C07D409/14;C07D417/14;C07D521/00 |
主分类号 |
C07D401/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|