| 摘要 |
A compound, or a solvate or salt thereof, of formula (I): <CHEM> in which R represents a group of formula (II) <CHEM> in which Rx is the remainder of a heterocyclic group, or an optionally substituted phenyl group; R1 and R2 are independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl or C4-12 cycloalkylalkyl groups, or together form a C2-8 branched or linear polymethylene or C2-6 alkenylene group, optionally substituted with a hetero-atom; R3 is hydrogen , C1-6 alkyl, or phenyl, or R3 together with R1 form a -(CH2)3- or -(CH2)4- group; R4 and R5, which may be located on the same or different carbon atoms, are independently hydrogen, C1-6 alkyl, or phenyl; m is 1, 2 or 3; R7 is hydrogen or C1-6 alkyl; n is O, 1 or 2; X is direct bond, or O, S or NR6 in which R6 is hydrogen or C1-6 alkyl; Y is >C=O, >CHOH, -S=O or - SO2; each of R8 and R9 is C1-6 alkyl, or R8 and R9 are linked together and R8 represents -(Z)p- where p is 0 or 1 and Z is O, S or NRz where Rz is hydrogen or C1-6 alkyl; and R9 represents -(CH2)q- where q is an integer of from 1 to 4, is useful for the treatment of pain or hyponatraemic disease states.
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