发明名称 PROCESS FOR PREPARATION OF N-SUBSTITUTED AMINOALKANE DIPHOSPHONIC ACIDS
摘要 Compounds of the formula I <IMAGE> (I) in which R1 is an aromatic radical, n is 0, 1, 2 or 3, X is an oxy group, a thio group which can be oxidized or an imino group which is unsubstituted or has aliphatic substituents, alk1 and alk2 are identical or different divalent aliphatic radicals, and R2 is hydrogen or a monovalent aliphatic radical and salts thereof have properties which regulate calcium metabolism and can be employed for the treatment of diseases connected with disturbances in this metabolism. They are prepared, for example, by reacting a compound of the formula <IMAGE> (V) in which X3 is carboxyl with a phosphorylating agent and hydrolysing the primary product.
申请公布号 HU901348(D0) 申请公布日期 1990.05.28
申请号 HU19900001348 申请日期 1990.03.07
申请人 CIBA-GEIGY AG.,CH 发明人 JAEGGI,KNUT A.,CH
分类号 A61K31/66;A61K31/675;A61P3/00;A61P3/14;A61P19/10;A61P35/00;A61P43/00;C07F9/38;C07F9/58;C07F9/6512 主分类号 A61K31/66
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