POLYPEPTIDE MARKER FOR ALZHEIMER'S DISEASE AND ITS USE FOR DIAGNOSIS

摘要

A POLYPEPTIDE MARKER FOR ALZHEIMER'S DISEASE AND ITS USE FOR DIAGNOSIS A novel polypeptide, Alzheimer's Amyloid Polypeptide (AAP), is provided in substantially purified form which 18 isolated from amyloid deposits in patients with Alzheimer's Disease. The polypeptide has the following amino acid sequence: H2N-ASP-AIA-GLU-PHE-ARG-HIS-ASP- SER-GLY-TYR-GLN-VAL-HIS-HIS-GLN- LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP- VAL-GLY-SER-ASN-LYS-COOH. The polypeptide, or fragmentS thereof, may be used to produce antibodies useful in a diagnostic test for Alzheimer's Disease. Nucleotide probes corresponding to portions of the polypeptide are also useful for diagnostic purposes.