| 发明名称 |
CLEAVABLE LINKERS FOR THE REDUCTION OF NON-TARGET ORGAN RETENTION OF IMMUNOCONJUGATES |
| 摘要 |
A process for reducing the non-target organ accumulation of immunoconjugates administered in vivo during therapeutic or diagnostic procedures involves the use of immunoconjugates comprising linkers that are cleavable at the non-target organs. The linkers are cleavable under conditions present, or induced, at one or more non-target organs, which include the kidneys or the liver. |
| 申请公布号 |
WO9003188(A1) |
申请公布日期 |
1990.04.05 |
| 申请号 |
WO1989US04266 |
申请日期 |
1989.09.29 |
| 申请人 |
NEORX CORPORATION |
发明人 |
ABRAMS, PAUL, G.;RENO, JOHN, M.;FRITZBERG, ALAN, R.;SRINIVASAN, ANANTHACHARI;ANDERSON, DAVID, C. |
| 分类号 |
A61K47/48;A61K51/08;A61K51/10;(IPC1-7):A61K43/00;C07K15/28;A61K39/00;A61K49/02 |
主分类号 |
A61K47/48 |
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