发明名称 |
PROCESS FOR THE PREPARATION OF TERTIARY CARBINOLS CONTAINING AN AMINIC SUBSTITUENT |
摘要 |
A process for the preparation of tertiary diphenyl carbinols containing a primary or secondary amine substituent on the aliphatic moiety attached to the carbinol function which consists in contacting a Grignard phenyl reagent with an aminoacid wherein the mobile protons are not masked in an aprotic inert organic solvent or a mixture thereof at a temperature between 20 DEG C and the boiling temperature by the reaction mixture. The reaction products are useful as active ingredients of medicaments and intermediates for the manufacture thereof. |
申请公布号 |
ZA8901134(B) |
申请公布日期 |
1990.03.28 |
申请号 |
ZA19890001134 |
申请日期 |
1989.02.14 |
申请人 |
GRUPPO LEPETIT S.P.A. |
发明人 |
ELVIO BELLASIO |
分类号 |
C07D223/04;A61K31/395;A61K31/55;A61P25/00;A61P43/00;C07C29/32;C07C33/24;C07C33/46;C07C213/00;C07C215/32;C07C217/66;C07D207/08;C07D211/22;C07D225/02 |
主分类号 |
C07D223/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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