PROCESS FOR PREPARATION OF 3-PHENYL-5,6-DILHYDROBENZ (C)-ACRIDINE-CARBOXYLIC-ACIDS AND CARBOXYLIC-ACID DERIVATIVES AND FOR MANUFACTURING OF PHARMACEUTICAL COMPOSITION CONTAINING THESE COMPOUNDS AS ACTIVE INGREDIENT

摘要

Dihydrobenz[c]acridine carboxylic acid derivatives are provided which are useful in treating tumors in mammals. These dihydrobenz[c]acridine carboxylic acid derivatives have the formula: or a pharmaceutically acceptable salt thereof, where R<1>, R<2>, R<3>, R<4> and R<5> are as defined in the specification. Also provided are pharmaceutical compositions of said compounds. In addition, processes for the preparation of these compounds are disclosed.