| 摘要 |
The present invention is dealing with new saccharides of the formula I: <CHEM> wherein X and Y represent a moiety selected from an optionally sulphated uronic acid moiety and a non-uronic acid spacer which consists of a linear or cyclic chain of atoms and carries at least one electronegatively charged substituent preferably a carboxylate group, provided that at least one of the moieties X or Y represents the said non-uronic acid spacer, R is hydrogen or alkyl (1-20 C), R<1>, R<2>, R<3>, R<4>, R<5> and R<6> represent hydrogen or the moiety SO3<->, R<7>, R<8>, R<9> represent OH, OSO3<->, NHSO3<-> or NH-acyl, These saccharides have anti-thrombotic activity and especially they activate thrombin via AT-III. The invention also refers to new intermediates in the synthesis of the above saccharides. |
