发明名称 |
PREPARATION OF CEPHALOSPORINS SUBSTITUTED IN THE 7-POSITION BY A HETEROCYCLIC GROUP |
摘要 |
<p>An improved process for preparing cephalosporins having a 7-position substituent of the formula:- <CHEM> wherein R<a> and R<b> represent hydrogen or alkyl or are joined to form a C3-5 cycloalkyl group, which comprises reacting a 7-amino cephalosporin with a compound of the formula:- <CHEM> wherein R<4> is hydrogen or an amino protecting group, R<1>, R<2> and R<3> are alkyl, aryl or arylalkyl and R<5> is the residue of a displaceable thioester group (R<5>SCO-) and subsequently removing the silyl group and, if necessary, the amino protecting group.</p> |
申请公布号 |
NZ220704(A) |
申请公布日期 |
1990.03.27 |
申请号 |
NZ19870220704 |
申请日期 |
1987.06.16 |
申请人 |
IMPERIAL CHEMICAL INDUSTRIES PLC |
发明人 |
ROBINSON, GRAHAM ERNEST;SQUIRE, CHRISTOPHER JOHN |
分类号 |
C07D501/20;C07D501/06;C07F7/18;(IPC1-7):C07D501/06;C07D277/40 |
主分类号 |
C07D501/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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