RETROVIRAL VECTORS EXPRESSING SOLUBLE CD4; A GENE THERAPY FOR AIDS

摘要

The invention disclosed herein provides a means of blocking retroviral infection of human cells by in vivo production of secreted CD4 (sCD4) molecule proteins and CD4 protein analogues. These proteins block interaction between the CD4 receptors on cells and virus, viral particles and viral products which would otherwise bind to the CD4 receptors.