Salmonella transformant capable of expression of heterologous genes and useful as a recombinant vaccine.

摘要

The invention provides a Salmonella baceterial strain transformed with an expression vector comprising a heterologous gene operatively linked to an E. coli promoter sequence, the transformed strain being capable of constitutive expression of the product of the heterologous gene. Also provided is an attenuated Salmonella strain containing all or a portion of a selected circumsporozoite protein, useful for inducing protective cell-mediated immunity to malarial parasites.