XANTHINE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS

摘要

100-6690 Xanthine derivatives of formula I wherein R1 is C1-4alkyl, C3-4alkenyl or C3-6cycloalkylmethyl,R2 is C1-4alkyl which is unsubstituted or substituted by one or more substituents selected from hydroxy, mercapto, C1-4alkoxy and C1-4alkylthio, R3 is hydrogen, halogen, hydroxy, C1-4alkoxy, amino or monoor di-(C1-4alkyl)amino and R4 and R5 are each independently halogen, hydroxy, C1-4alkoxy, amino, mono- or di-(C1-4alkyl) amino or together represent a methylene dioxy group (-O-CH2-O-)-bridging adjacent positions on the phenyl ring, and the physiologically-hydrolysable and -acceptable esters and amides thereof; which compounds are indicated for use as pharmaceuticals in particular for treating asthma and bronchitis.