发明名称 |
METHOD FOR PURIFICATION OF FILAMENTOUS HEMAGGLUTININ |
摘要 |
<p>Improved method for the purification of filamentous hemagglutinin (F-HA) on industrial scale which comprises contacting a culture of a microorganism of the genus Bordetella with a cellulose sulfate gel, a polysaccharide gel chemically bound with dextran sulfate, or a crosslinked polysaccharide sulfate gel, thereby adsorbing F-HA on the gel, and then eluting F-HA from the gel. Said method can give a highly purified F-HA which does not contain any other proteins, lipid, saccharides, etc. and further undesirable endotoxin, and hence can be used for producing various reagents, medicines and pertussis vaccine.</p> |
申请公布号 |
EP0159003(B1) |
申请公布日期 |
1990.02.28 |
申请号 |
EP19850104545 |
申请日期 |
1985.04.15 |
申请人 |
JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE |
发明人 |
GINNAGA, AKIHIRO;SAKUMA, SHIN;NISHIHARA, TSUKASA C/O JURIDICAL FOUNDATION;TASHIRO, TOMITAKA;SUSUMI, SADAO;KAWAHARA, TETSUO;MIZOKAMI, HIROSHI |
分类号 |
C12P21/00;A61K39/00;C07K14/235 |
主分类号 |
C12P21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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