| 摘要 |
Compounds are disclosed of formula (I) <CHEM> wherein R1 represents hydroxy, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 carboxyalkyl, phenyl, oxo, amino, carboxy, amido, -NR4COR5 (where R4 and R5 both represent C1-6 alkyl), optionally substituted methylidene or, together with the carbon atom to which it is attached, R1 forms a 5 or 6-membered ring containing one or more heteroatoms; R2 and R3 are the same or different and are C1-6 alkyl or C3-6 alkenyl; or -NR2R3 forms a 5-membered (optionally containing an oxygen atom adjacent to the nitrogen) or a 6-membered ring, which ring optionally contains one unit of unsaturation and which is unsubstituted or substituted by hydroxy, oxo, optionally substituted methylidene, -COR6 (where R6 represents C1-6 alkyl, OR7 or -NHR7, and R7 represents hydrogen, C1-6 alkyl, aryl, ar(C1-6)alkyl) or =NOR8 (where R8 represents C1-6 alkyl); X represents a direct bond, -CH2- or -CH2O-; Ar represents a substituted phenyl moiety; and physiologically acceptable salts thereof. The compounds are indicated as useful for the treatment of pain and cerebral ischaemia. Processes and intermediates for their preparation and pharmaceutical compositions containing them are also disclosed. |
