PROCESS FOR THE PREPARATION OF ERGOLINE DERIVATIVES

摘要

(8 beta )-N-heteroalkyl-1- alkyl-6-(substituted) ergoline-8-carboxamides of the formula wherein: R<1> is C1-C4 alkyl; R<2> is allyl or C1-C4 straight chain alkyl; R<3> is hydrogen or C1-C4 straight chain alkyl; R<4> is pyridinyl or imidazolyl; alk is a divalent organic radical derived from a straight or branched C1-C5 alkane; or a pharmaceutically acceptable acid addition salt thereof. The compounds are useful for blocking 5HT2 receptors in mammals having an excess of serotonin centrally or peripherally